Free Glycogen in Vaginal Fluids Is Associated with Lactobacillus Colonization and Low Vaginal pH

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Free Glycogen in Vaginal Fluids Is Associated with Lactobacillus Colonization and Low Vaginal pH

OBJECTIVE Lactobacillus dominates the lower genital tract microbiota of many women, producing a low vaginal pH, and is important for healthy pregnancy outcomes and protection against several sexually transmitted pathogens. Yet, factors that promote Lactobacillus remain poorly understood. We hypothesized that the amount of free glycogen in the lumen of the lower genital tract is an important det...

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Maternal Recto-Vaginal Organisms and Surface Skin Colonization in Infants

Background: Early-onset sepsis is a common cause of neonatal mortality and mainly occurs due to the colonized microorganisms in the maternal recto-vaginal area. The present study aimed to evaluate the effects of maternal risk factors on recto-vaginal colonization and transmission rate of micro-flora from mothers to infants. Methods: Upon admission, two samples were obtained from the distal thi...

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Effect of pH on Cleavage of Glycogen by Vaginal Enzymes

Glycogen expressed by the lower genital tract epithelium is believed to support Lactobacillus growth in vivo, although most genital isolates of Lactobacillus are not able to use glycogen as an energy source in vitro. We recently reported that α-amylase is present in the genital fluid of women and that it breaks down glycogen into small carbohydrates that support growth of lactobacilli. Since th...

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Uterus Dysplasia Associated with Cervico-Vaginal Agenesis

Müllerian ducts can form upper parts of normal female reproductive system and any failure in ductal fusion may lead to Müllerian Duct Anomalies (MDA). We present a case of MDA, a uterus dysplasia with no evidence of cervical or upper vaginal tissue. This case illustrates the role of Magnetic Resonance Imaging (MRI) on MDA diagnosis and urges the need for a unified reliable and practical classif...

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The presence of an abnormal vaginal microflora in early pregnancy is a risk factor for preterm delivery. There is no investigation on vaginal flora dominated by lactic acid bacteria and possible association with preterm delivery. We assessed the dominant vaginal Lactobacillus species in healthy pregnant women in early pregnancy in relation to pregnancy outcome. We observed 111 low risk pregnant...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2014

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0102467